A.K.M Shafiqul Islam
BIRDEM General Hospital, Bangladesh
Title: Correlation between serum complement C3 and FIB4 Index with stages of fibrosis of liver by fibroscan in NAFLD patients
Biography
Biography: A.K.M Shafiqul Islam
Abstract
Introduction & Objective: Despite the high prevalence of NAFLD non-invasive markers of disease activity and severity remain limited. Different modalities are available for predicting severity of NAFLD with different sensitivity and specificity. A single, cheap, widely available marker with high sensitivity and specificity is yet to be identified. The current study intends to find out the utility of serum complement C3 and FIB4 Index to predict stages of fibrosis of liver in NAFLD patients.
Method: This observational cross-sectional study was done at department of GHPD, BIRDEM General Hospital, Dhaka, during the period of January 2016 to October 2017. A total of 105 sonographically diagnosed NAFLD subjects attending at OPD and admitted in that Hospital were included in the study. Statistical analysis was done with SPSS version 16.
Result: Out of 105 subjects, 70 (66.7%) were female and 35 (33.3%) male. Serum complement C3 (mg/dl) 142.30±21.02 (mean±SD). USG of W/A or HBS showed 61 (58.10%) had grade I, 33 (31.43%) grade II, 11 (10.48%) grade III fatty liver disease. Fibroscan showed no fibrosis in 31 (29.52%), F1 stage of fibrosis in 22 (20.95%) and F2 in 22 (20.95%). FIB4 Index was 1.22±0.76 (mean±SD). Pearson correlation test showed stages of fibrosis by fibroscan had significant positive correlation with FIB4 index, weak positive correlation with BMI (kg/m2), weak negative correlation with serum complement C3 and almost no correlation with grading of fatty liver on USG (Spearman’s correlation).
Conclusion: The positive correlation of stages of fibrosis by fibroscan with FIB4 index was significant whereas negative correlation with serum complement C3 was not so significant statistically. Sensitivity and specificity of serum complement C3 and FIB 4 index as fibrosis marker was not so significant. Serum complement C3 and FIB4 index may not be used as a marker of severity of fibrosis.